The Bst locus on mouse chromosome 16 is associated with age-related subretinal neovascularization

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The bst locus on mouse chromosome 16 is associated with age-related subretinal neovascularization.

Ocular neovascularization is the leading cause of blindness in developed countries and often causes rapid loss of vision in age-related macular degeneration. Acute visual loss is most often due to hemorrhage from new vessels that have extended from the choroid into the subretinal space. Growth of abnormal vessels beneath the retina in this condition is known as subretinal neovascularization (SR...

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Subretinal choroidal neovascularization associated with choroidal nevus.

PURPOSE Evaluation of a large series of choroidal nevi inducing the formation of a neovascular membrane in order to more clearly define the clinical presentation and to evaluate the efficacy of various treatment options. METHOD Retrospective study of 22 clinical cases. RESULTS All nevi were situated in the posterior choroid. They had a mean diameter of 3.8 mm and a mean thickness of 1.4 mm....

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A susceptibility locus for radiation lymphomagenesis on mouse chromosome 16.

BALB/cHeA (BALB/c) mice are sensitive to radiation lymphomagenesis, while STS/A (STS) mice are resistant. We have selected a recombinant mouse, R1, with a STS-derived D16Mit165-D16Mit34 segment in the vicinity of the centromere of chromosome 16 among progeny from a (CcS-7/Dem x BALB/c)F1 x BALB/c backcross. To test the susceptibility to radiation lymphomagenesis, we generated a genetic cross by...

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The mouse deafness locus (dn) is associated with an inversion on chromosome 19.

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CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration.

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ژورنال

عنوان ژورنال: Proceedings of the National Academy of Sciences

سال: 2000

ISSN: 0027-8424,1091-6490

DOI: 10.1073/pnas.040531597